Title : Nitric oxide mediates the amplification by interleukin-1 beta of neurogenic vasodilatation in the rat skin.

Pub. Date : 1994 Jul 21

PMID : 7957631






3 Functional Relationships(s)
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1 Intraplantar injection of interleukin-1 beta (50 pg) significantly enhanced the hyperaemic response to intraplantar capsaicin (0.3 microgram). Capsaicin interleukin 1 beta Rattus norvegicus
2 Pretreatment with a neurotoxic dose of capsaicin reduced the capsaicin-evoked hyperaemia and prevented the facilitatory effect of interleukin-1 beta. Capsaicin interleukin 1 beta Rattus norvegicus
3 These data indicate that the enhancement by interleukin-1 beta of the capsaicin-induced hyperaemia involves thin afferent nerve fibres and depends on nitric oxide as essential intermediate. Capsaicin interleukin 1 beta Rattus norvegicus