Title : Mutations to amino acids located in predicted transmembrane segment 6 (TM6) modulate the activity and substrate specificity of human P-glycoprotein.

Pub. Date : 1994 Nov 29

PMID : 7947814






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Mutation of Val338 to Ala resulted in a mutant P-glycoprotein which conferred enhanced resistance to colchicine and reduced relative resistance to vinblastine. Colchicine ATP binding cassette subfamily B member 1 Homo sapiens