Title : Induction of rat alpha-1-acid glycoprotein by phenobarbital is independent of a general acute-phase response.

Pub. Date : 1994 Oct 7

PMID : 7945456






4 Functional Relationships(s)
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1 Phenobarbital (PB) induces transcription of the alpha 1-acid glycoprotein (AGP) gene, one of the major positive acute-phase proteins, the expression of which is controlled by a specific combination of glucocorticoids and cytokines. Phenobarbital orosomucoid 1 Rattus norvegicus
2 Phenobarbital (PB) induces transcription of the alpha 1-acid glycoprotein (AGP) gene, one of the major positive acute-phase proteins, the expression of which is controlled by a specific combination of glucocorticoids and cytokines. Phenobarbital orosomucoid 1 Rattus norvegicus
3 Glucocorticoid involvement is also ruled out by the observed enhancement of the effect of PB on AGP expression in adrenalectomized animals. Phenobarbital orosomucoid 1 Rattus norvegicus
4 Our results suggest that phenobarbital acts on AGP expression by a mechanism independent of the inflammatory pathway. Phenobarbital orosomucoid 1 Rattus norvegicus