Title : Characterization of phorbol ester-stimulated serine phosphorylation of the human insulin receptor.

Pub. Date : 1994 Oct 1

PMID : 7945263






6 Functional Relationships(s)
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1 Phorbol 12-myristate 13-acetate (PMA)-stimulated phosphorylation of the human insulin receptor (IR) was characterized and compared in two cell types of different lineage: normal rat kidney epithelial (NRK) cells and Chinese hamster ovary (CHO) fibroblasts. Tetradecanoylphorbol Acetate insulin receptor Homo sapiens
2 Phorbol 12-myristate 13-acetate (PMA)-stimulated phosphorylation of the human insulin receptor (IR) was characterized and compared in two cell types of different lineage: normal rat kidney epithelial (NRK) cells and Chinese hamster ovary (CHO) fibroblasts. Tetradecanoylphorbol Acetate insulin receptor Homo sapiens
3 Tryptic phosphopeptide analysis by Tricine/SDS/PAGE revealed significant differences in the PMA-stimulated phosphorylation of the IR in these two cell types. Tetradecanoylphorbol Acetate insulin receptor Homo sapiens
4 These results demonstrate that PMA-stimulated phosphorylation of the IR can exhibit significant differences when expressed in different cell types, and that Ser1315 is a major PMA-stimulated phosphorylation site on the human IR. Tetradecanoylphorbol Acetate insulin receptor Homo sapiens
5 These results demonstrate that PMA-stimulated phosphorylation of the IR can exhibit significant differences when expressed in different cell types, and that Ser1315 is a major PMA-stimulated phosphorylation site on the human IR. Tetradecanoylphorbol Acetate insulin receptor Homo sapiens
6 These results demonstrate that PMA-stimulated phosphorylation of the IR can exhibit significant differences when expressed in different cell types, and that Ser1315 is a major PMA-stimulated phosphorylation site on the human IR. Tetradecanoylphorbol Acetate insulin receptor Homo sapiens