Title : 5-Aminosalicylic acid inhibits leukotriene B4 omega-hydroxylase activity in human polymorphonuclear leukocytes.

Pub. Date : 1994 Jun

PMID : 7938083






3 Functional Relationships(s)
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1 5-Aminosalicylic acid inhibits leukotriene B4 omega-hydroxylase activity in human polymorphonuclear leukocytes. Mesalamine cytochrome P450 family 4 subfamily F member 3 Homo sapiens
2 To investigate the action of 5-aminosalicylic acid (5-ASA) on LTB4 omega-hydroxylase activity, we incubated human polymorphonuclear leukocytes (PMNLs) with 3H-labeled LTB4 after pre-incubation with various concentrations of 5-ASA. Mesalamine cytochrome P450 family 4 subfamily F member 3 Homo sapiens
3 LTB4 omega-hydroxylase activity was inhibited by 5-ASA in a concentration-dependent fashion. Mesalamine cytochrome P450 family 4 subfamily F member 3 Homo sapiens