Title : Positive and negative regulation of the composite octamer motif of the interleukin 2 enhancer by AP-1, Oct-2, and retinoic acid receptor.

Pub. Date : 1994 Oct 1

PMID : 7931079






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 OAP confers to Oct-2 responsivity to both TPA/Ca2+ and RA, since specific mutations of the AP-1/OAP-binding site significantly reduce the transactivation by Oct-2 in response to TPA and Ca2+ and abolish the inhibition by RA. Tretinoin Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens
2 OAP confers to Oct-2 responsivity to both TPA/Ca2+ and RA, since specific mutations of the AP-1/OAP-binding site significantly reduce the transactivation by Oct-2 in response to TPA and Ca2+ and abolish the inhibition by RA. Tretinoin Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens