Title : Synergism between interleukins 1 beta and 6 on noradrenergic nerves in rat myenteric plexus.

Pub. Date : 1994 Oct

PMID : 7926489






4 Functional Relationships(s)
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1 RESULTS: 1 ng/mL of IL-6 augmented 3H release, 100 ng/mL suppressed 3H release, whereas 10 ng/mL had no effect. Tritium interleukin 6 Homo sapiens
2 However, IL-6 (10 ng/mL) plus a subthreshold concentration of human recombinant IL-1 beta significantly suppressed 3H release, and this was abolished by adding anti-IL-6 antibody or an IL-1 receptor antagonist. Tritium interleukin 6 Homo sapiens
3 However, IL-6 (10 ng/mL) plus a subthreshold concentration of human recombinant IL-1 beta significantly suppressed 3H release, and this was abolished by adding anti-IL-6 antibody or an IL-1 receptor antagonist. Tritium interleukin 6 Homo sapiens
4 CONCLUSIONS: Because 3H release reflects [3H]norepinephrine release, our results show that IL-6 exerts a dual effect on norepinephrine release. Tritium interleukin 6 Homo sapiens