Title : Thrombin-induced platelet aggregation, phosphoinositide metabolism and protein phosphorylation in NIDDM patients treated by diet, sulphonylurea or insulin.

Pub. Date : 1994 Jun

PMID : 7926350






1 Functional Relationships(s)
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1 These results suggest that sulphonylureas and insulin induce suppression of thrombin-induced activation of phospholipase C, which mediates hydrolysis of PIP and PIP2 and production of PA, which leads to inhibition of platelet aggregation. Phosphatidylinositol 4,5-Diphosphate coagulation factor II, thrombin Homo sapiens