Title : Characterization of EP-receptor subtypes involved in allodynia and hyperalgesia induced by intrathecal administration of prostaglandin E2 to mice.

Pub. Date : 1994 Jul

PMID : 7921597






2 Functional Relationships(s)
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1 17-Phenyl-omega-trinor PGE2 (EP1 > EP3) and 16,16-dimethyl PGE2 (EP1 = EP2 = EP3) were as potent as PGE2 in inducing allodynia, and more potent than sulprostone. Dinoprostone prostaglandin E receptor 3 (subtype EP3) Mus musculus
2 These results demonstrate that PGE2 may exert allodynia through the EP1-receptor and hyperalgesia through EP2- and EP3-receptors in the mouse spinal cord. Dinoprostone prostaglandin E receptor 3 (subtype EP3) Mus musculus