Title : TNF cytotoxicity: effects of HER-2/neu expression and inhibitors of ADP-ribosylation.

Pub. Date : 1994 Apr

PMID : 7914750






1 Functional Relationships(s)
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1 In short-term 51Cr-release assays with several mouse and human tumor cell lines, the inhibitors aminobenzamide (ABA) and nicotinamide (NA) of ADP-ribosylation sensitized HER-2/neu-nonoverexpressing cells (CaOV-3 and MCF-7) but not HER-2/neu-overexpressing cells (SKOV-3 and SKBR-3) to TNF. Niacinamide tumor necrosis factor Homo sapiens