Title : Point mutation within the tyrosine kinase domain of the RET proto-oncogene in multiple endocrine neoplasia type 2B and related sporadic tumours.

Pub. Date : 1994 Feb

PMID : 7911697






1 Functional Relationships(s)
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1 We now report a missense mutation, resulting in the substitution of a threonine for a methionine at codon 918 in the tyrosine kinase catalytic domain, in the germline of 26 of 28 apparently distinct families with MEN 2B. Threonine ret proto-oncogene Homo sapiens