Title : Inhibitory effects of magnesium hydroxide on c-myc expression and cell proliferation induced by methylazoxymethanol acetate in rat colon.

Pub. Date : 1993 Dec 10

PMID : 7904896






2 Functional Relationships(s)
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1 The effects of magnesium hydroxide were examined on methylazoxymethanol (MAM) acetate-induced c-myc expression and cell proliferation of colonic mucosal epithelium in rats. methylazoxymethanol MYC proto-oncogene, bHLH transcription factor Rattus norvegicus
2 Magnesium hydroxide inhibited the MAM-induced expression of c-myc proto-oncogene, and also suppressed the increased bromodeoxyuridine (BrdU) and proliferating cell nuclear antigen (PCNA) labelling indexes induced by MAM acetate in colon mucosa in initiation and post-initiation phase. methylazoxymethanol MYC proto-oncogene, bHLH transcription factor Rattus norvegicus