Title : N-(p-azido-3-[125I]iodophenethyl)spiperone binds to specific regions of P-glycoprotein and another multidrug binding protein, spiperophilin, in human neuroblastoma cells.

Pub. Date : 1994 Jan 11

PMID : 7904476






1 Functional Relationships(s)
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1 [125I]NAPS photolabeling of P-gp was preferentially competed by MDR-related drugs, with vinblastine > VCR > colchicine > doxorubicin > actinomycin D. Many drugs that are known to reverse MDR were potent inhibitors of [125I]NAPS binding to P-gp. Colchicine ATP binding cassette subfamily B member 1 Homo sapiens