Title : NMDA receptor antagonist decreases the progesterone-induced increase in GnRH gene expression in the rat hypothalamus.

Pub. Date : 1993 Aug

PMID : 7903433






3 Functional Relationships(s)
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1 Recent studies indicate that excitatory amino acids may play an important role in the regulation of GnRH secretion and gene expression by steroids. Excitatory Amino Acids gonadotropin releasing hormone 1 Rattus norvegicus
2 Therefore the present study attempts to examine whether excitatory amino acids are involved in the P-induced GnRH gene expression and release in vitro. Excitatory Amino Acids gonadotropin releasing hormone 1 Rattus norvegicus
3 These results clearly indicate that excitatory amino acids by way of NMDA receptor are involved in the transsynaptic regulation of GnRH gene expression. Excitatory Amino Acids gonadotropin releasing hormone 1 Rattus norvegicus