Title : p53-dependent and p53-independent activation of apoptosis in mammary epithelial cells reveals a survival function of EGF and insulin.

Pub. Date : 1995 Mar

PMID : 7896881






2 Functional Relationships(s)
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1 Upon introduction of temperature-sensitive p53 into HC11 cells, which lack wild-type (wt) p53, PCD was observed after mitomycin treatment at 32 degrees, when the ts p53 protein is in wt conformation. Mitomycin tumor protein p53 Homo sapiens
2 Thus, wt p53 mediates activation of PCD in response to mitomycin in HC11 cells. Mitomycin tumor protein p53 Homo sapiens