Title : Mutation of glycine 185 to valine alters the ATPase function of the human P-glycoprotein expressed in Sf9 cells.

Pub. Date : 1995 Mar 24

PMID : 7896810






2 Functional Relationships(s)
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1 Verapamil- and colchicine-stimulated ATPase activities were markedly increased with concomitant increase in affinity for these compounds with Gly185-->Val substitution in the Pgp. Colchicine ATP binding cassette subfamily B member 1 Homo sapiens
2 Because transport substrate-induced ATP hydrolysis is generally thought to reflect transport function, these data suggest that colchicine and verapamil are transported at an increased rate with Gly185-->Val substitution in the Pgp. Colchicine ATP binding cassette subfamily B member 1 Homo sapiens