Title : Structure-activity relationships for the 8-alkylpterins: a new class of mechanism-based substrates for dihydrofolate reductase (DHFR).

Pub. Date : 1995 Mar 21

PMID : 7893669






1 Functional Relationships(s)
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1 Comparison of Kd values with corresponding Km values suggested both strong cooperativity (6,8-dimethylpterin) and antagonism (6-methyl-8-isopropylpterin) with NADPH in binding to DHFR. NADP dihydrofolate reductase Gallus gallus