Pub. Date : 1994 Nov
PMID : 7882901
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | When tested by RIA or by the Nb2 bioassay, there appeared to be approximately 50% less PRL secreted (2 weeks post-injection) by cells of the NMU-treated than the vehicle-treated animals. | Methylnitrosourea | prolactin | Rattus norvegicus |
| 2 | However, when tested by IL-2R assay, PRL cells of NMU-treated animals secreted 50% more activity. | Methylnitrosourea | prolactin | Rattus norvegicus |
| 3 | Our interpretation is that NMU treatment interferes with the feedback of lymphokines on the pituitary with a decrease in the form of PRL detected by the RIA and Nb2 assays and an increase in the form which activates splenocytes, and thus changes the composition and function of the immune system. | Methylnitrosourea | prolactin | Rattus norvegicus |