Pub. Date : 1995 Jan 27
PMID : 7874687
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Using a cell line derived from the D2 tumor, we have demonstrated the effect of the aromatase substrate, androstenedione, on the proliferation of tumor cells. | Androstenedione | cytochrome P450 family 19 subfamily A member 1 | Homo sapiens |
| 2 | Proliferative effects of androstenedione were blocked by an aromatase inhibitor, providing evidence for the role of int-5/aromatase in this process. | Androstenedione | cytochrome P450 family 19 subfamily A member 1 | Homo sapiens |
| 3 | Proliferative effects of androstenedione were blocked by an aromatase inhibitor, providing evidence for the role of int-5/aromatase in this process. | Androstenedione | cytochrome P450 family 19 subfamily A member 1 | Homo sapiens |
| 4 | Furthermore, the androstenedione-mediated proliferation was inhibited by the addition of anti-estrogen ICI 164,384, suggesting that the estrogen formed from the conversion of androstenedione by int-5/aromatase acts like a mitogen to stimulate the growth of D2 tumor cells. | Androstenedione | cytochrome P450 family 19 subfamily A member 1 | Homo sapiens |
| 5 | Furthermore, the androstenedione-mediated proliferation was inhibited by the addition of anti-estrogen ICI 164,384, suggesting that the estrogen formed from the conversion of androstenedione by int-5/aromatase acts like a mitogen to stimulate the growth of D2 tumor cells. | Androstenedione | cytochrome P450 family 19 subfamily A member 1 | Homo sapiens |