Title : Acyclic guanosine analogs inhibit DNA polymerases alpha, delta, and epsilon with very different potencies and have unique mechanisms of action.

Pub. Date : 1995 Feb 28

PMID : 7873530






1 Functional Relationships(s)
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1 Each triphosphate preferentially inhibited pol delta, although ganciclovir triphosphate was the most impressive of the three; the Ki for inhibition of pol delta was 2 microM (competitive with dGTP), while the Kis for inhibition of pol alpha and epsilon were 80 and 140 microM, respectively. triphosphoric acid DNA polymerase alpha 1, catalytic subunit Homo sapiens