Pub. Date : 1995 Feb 17
PMID : 7852388
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Our findings indicate that GM1-promoted survival can be mediated in part by the Trk NGF receptor as well as by TrkB, and potentially by tyrosine kinase receptors for additional neurotrophic growth factors. | G(M1) Ganglioside | neurotrophic receptor tyrosine kinase 1 | Rattus norvegicus |
| 2 | Experiments employing K-252a, an inhibitor of Trk kinases, and PC12 cells overexpressing a dominant inhibitory form of Trk both indicate that a portion of the survival-promoting activity of GM1 is evoked by receptor dimerization and autophosphorylation. | G(M1) Ganglioside | neurotrophic receptor tyrosine kinase 1 | Rattus norvegicus |
| 3 | Experiments employing K-252a, an inhibitor of Trk kinases, and PC12 cells overexpressing a dominant inhibitory form of Trk both indicate that a portion of the survival-promoting activity of GM1 is evoked by receptor dimerization and autophosphorylation. | G(M1) Ganglioside | neurotrophic receptor tyrosine kinase 1 | Rattus norvegicus |
| 4 | In consonance with this we find that GM1 stimulates Trk tyrosine autophosphorylation and Trk-associated protein kinase activity. | G(M1) Ganglioside | neurotrophic receptor tyrosine kinase 1 | Rattus norvegicus |
| 5 | In consonance with this we find that GM1 stimulates Trk tyrosine autophosphorylation and Trk-associated protein kinase activity. | G(M1) Ganglioside | neurotrophic receptor tyrosine kinase 1 | Rattus norvegicus |