Title : Oxidation of bromide by the human leukocyte enzymes myeloperoxidase and eosinophil peroxidase. Formation of bromamines.

Pub. Date : 1995 Feb 17

PMID : 7852368






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Oxidation of bromide by the human leukocyte enzymes myeloperoxidase and eosinophil peroxidase. Bromides myeloperoxidase Homo sapiens
2 Myeloperoxidase and eosinophil peroxidase catalyzed the oxidation of bromide ion by hydrogen peroxide (H2O2) and produced a brominating agent that reacted with amine compounds to form bromamines, which are long-lived oxidants containing covalent nitrogen-bromine bonds. Bromides myeloperoxidase Homo sapiens
3 In the presence of physiologic levels of both bromide (0.1 mM) and chloride (0.1 M), myeloperoxidase and eosinophil peroxidase produced mixtures of bromamines and chloramines containing 6 +/- 4% and 88 +/- 4% bromamine. Bromides myeloperoxidase Homo sapiens