Pub. Date : 1995 Jan 10
PMID : 7840637
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Both the constitutive and phenobarbital-inducible expression of Cyp2b-9 and Cyp2b-10 mRNA decreased rapidly after transferring the hepatocytes to monolayer culture. | Phenobarbital | cytochrome P450, family 2, subfamily b, polypeptide 9 | Mus musculus |
| 2 | However, in spheroid culture, the Cyp2b-9 and Cyp2b-10 mRNAs were induced by phenobarbital at high levels for at least 4 days either with continuous exposure from the start of cultivation or for 24 h before harvesting. | Phenobarbital | cytochrome P450, family 2, subfamily b, polypeptide 9 | Mus musculus |
| 3 | There was more Cyp2b-10 species than those of Cyp2b-9 after exposure to phenobarbital both in vivo and in vitro. | Phenobarbital | cytochrome P450, family 2, subfamily b, polypeptide 9 | Mus musculus |
| 4 | Although the expression levels of both Cyp2b-9 and Cyp2b-10 species was very low in hepatocytes cultured without dexamethasone even in the presence of phenobarbital, the addition of 10(-7) or 10(-6) M dexamethasone caused an increase in the mRNA. | Phenobarbital | cytochrome P450, family 2, subfamily b, polypeptide 9 | Mus musculus |