Title : Local L-NG-monomethyl-arginine attenuates the vasodilator action of bradykinin in the human forearm.

Pub. Date : 1994 Oct

PMID : 7833219






5 Functional Relationships(s)
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1 Local L-NG-monomethyl-arginine attenuates the vasodilator action of bradykinin in the human forearm. omega-N-Methylarginine kininogen 1 Homo sapiens
2 In this study the effects of a specific inhibitor of nitric oxide synthase, L-NG-monomethyl-arginine (L-NMMA) and noradrenaline on the vasodilator responses to bradykinin were examined in the forearm arterial bed of healthy volunteers. omega-N-Methylarginine kininogen 1 Homo sapiens
3 In this study the effects of a specific inhibitor of nitric oxide synthase, L-NG-monomethyl-arginine (L-NMMA) and noradrenaline on the vasodilator responses to bradykinin were examined in the forearm arterial bed of healthy volunteers. omega-N-Methylarginine kininogen 1 Homo sapiens
4 The response to bradykinin, but not that to GTN, was attenuated by L-NMMA compared with noradrenaline (P < 0.05; n = 6), suggesting that bradykinin-induced vasodilatation in the forearm is mediated, at least in part, by stimulating release of nitric oxide. omega-N-Methylarginine kininogen 1 Homo sapiens
5 The response to bradykinin, but not that to GTN, was attenuated by L-NMMA compared with noradrenaline (P < 0.05; n = 6), suggesting that bradykinin-induced vasodilatation in the forearm is mediated, at least in part, by stimulating release of nitric oxide. omega-N-Methylarginine kininogen 1 Homo sapiens