Pub. Date : 1994 Dec
PMID : 7819095
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Haemoglobin inhibits GTP-hydrolysis and GDP/GTP-exchange activities of a low M(r) GTP-binding protein, ras p21. | Guanosine Triphosphate | H3 histone pseudogene 16 | Homo sapiens |
| 2 | Haemoglobin inhibits GTP-hydrolysis and GDP/GTP-exchange activities of a low M(r) GTP-binding protein, ras p21. | Guanosine Triphosphate | H3 histone pseudogene 16 | Homo sapiens |
| 3 | Haemoglobin was observed to inhibit the GDP/GTP-exchange activity of ras protein (ras p21) by measurement of [3H]GDP-dissociation activity in time- and dose-dependent manners. | Guanosine Triphosphate | H3 histone pseudogene 16 | Homo sapiens |
| 4 | Haemoglobin also inhibited the [32P]GTP-hydrolysis activity of ras p21 time- and dose-dependently. | Guanosine Triphosphate | H3 histone pseudogene 16 | Homo sapiens |
| 5 | Globin showed limited inhibition on the [32P]GTP-hydrolysis activity of ras p21, and haemin had no effect, indicating that the ternary tetrameric structure of haemoglobin is essential for the inhibitory effects on ras p21 activities. | Guanosine Triphosphate | H3 histone pseudogene 16 | Homo sapiens |
| 6 | Methaemoglobin also inhibited both [3H]GDP-dissociation and [32P]GTP-hydrolysis activities of ras p21 in a very similar manner to that by haemoglobin. | Guanosine Triphosphate | H3 histone pseudogene 16 | Homo sapiens |
| 7 | The obtained results strongly suggest that haemoglobin suppresses the physiological function(s) of ras p21 in vivo inhibiting both [32P]GTP-hydrolysis and GDP/GTP-dissociation of ras p21 in erythrocytes. | Guanosine Triphosphate | H3 histone pseudogene 16 | Homo sapiens |
| 8 | The obtained results strongly suggest that haemoglobin suppresses the physiological function(s) of ras p21 in vivo inhibiting both [32P]GTP-hydrolysis and GDP/GTP-dissociation of ras p21 in erythrocytes. | Guanosine Triphosphate | H3 histone pseudogene 16 | Homo sapiens |
| 9 | The obtained results strongly suggest that haemoglobin suppresses the physiological function(s) of ras p21 in vivo inhibiting both [32P]GTP-hydrolysis and GDP/GTP-dissociation of ras p21 in erythrocytes. | Guanosine Triphosphate | H3 histone pseudogene 16 | Homo sapiens |