Pub. Date : 1994 Sep
PMID : 7812678
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Regulation of lipopolysaccharide-induced tumor necrosis factor alpha production by endogenous prostaglandin E2 in rat resident and thioglycollate-elicited macrophages. | Thioglycolates | tumor necrosis factor | Rattus norvegicus |
| 2 | However, we have observed that a cyclooxygenase inhibitor had different effects on TNF alpha production by resident and thioglycollate-elicited rat peritoneal macrophages. | Thioglycolates | tumor necrosis factor | Rattus norvegicus |
| 3 | The addition of free arachidonic acid to cultures of LPS-stimulated, thioglycollate-elicited macrophages elevated PGE2 production and suppressed TNF alpha production in a manner similar to that observed with LPS-stimulated resident macrophages. | Thioglycolates | tumor necrosis factor | Rattus norvegicus |
| 4 | Instead, the inability of indomethacin to increase TNF alpha production by thioglycollate-elicited versus resident macrophages appears to result from an inability to release arachidonate efficiently and a lower initial level of cyclooxygenase, in thioglycollate-elicited macrophages. | Thioglycolates | tumor necrosis factor | Rattus norvegicus |