Title : A haemorrhagic platelet disorder associated with altered stimulus-response coupling and abnormal membrane phospholipid composition.

Pub. Date : 1994 Sep

PMID : 7803235






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Polyphosphoinositide metabolism and phosphatidic acid generation were diminished in thrombin-stimulated platelets, as was phosphorylation of the 47 kD substrate for protein kinase C and the 20 kD protein myosin light chain kinase, indicating impaired generation of the intracellular second messengers diacylglycerol and inositol trisphosphate due to diminished stimulated phospholipase C activity. Phosphatidylinositol Phosphates coagulation factor II, thrombin Homo sapiens