Title : Tumor necrosis factor-induced hepatic DNA fragmentation as an early marker of T cell-dependent liver injury in mice.

Pub. Date : 1995 Jul

PMID : 7797015






3 Functional Relationships(s)
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1 METHODS: Anti-CD3 monoclonal antibody or staphylococcal enterotoxin B was injected into mice sensitized by D-galactosamine. Galactosamine CD3 antigen, epsilon polypeptide Mus musculus
2 RESULTS: Mice sensitized with D-galactosamine developed severe liver injury within 8 hours after injection of anti-CD3 monoclonal antibody or staphylococcal enterotoxin B. Apoptotic bodies and chromatin condensation were detectable 5 hours after anti-CD3 monoclonal antibody challenge. Galactosamine CD3 antigen, epsilon polypeptide Mus musculus
3 RESULTS: Mice sensitized with D-galactosamine developed severe liver injury within 8 hours after injection of anti-CD3 monoclonal antibody or staphylococcal enterotoxin B. Apoptotic bodies and chromatin condensation were detectable 5 hours after anti-CD3 monoclonal antibody challenge. Galactosamine CD3 antigen, epsilon polypeptide Mus musculus