Title : Erythromycin shortens neutrophil survival by accelerating apoptosis.

Pub. Date : 1995 Apr

PMID : 7785987






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Erythromycin increased intracellular levels of cyclic AMP (cAMP) to 150% of control levels in neutrophils. Erythromycin cathelicidin antimicrobial peptide Homo sapiens
2 H-89, an inhibitor of cAMP-dependent protein kinase A, partially blocked the survival-shortening effect of erythromycin. Erythromycin cathelicidin antimicrobial peptide Homo sapiens
3 Our findings suggest that erythromycin shortens neutrophil survival at least in part through elevation of intracellular cAMP levels. Erythromycin cathelicidin antimicrobial peptide Homo sapiens