Title : Interaction of beta-carboline inverse agonists for the benzodiazepine site with another site on GABAA receptors.

Pub. Date : 1995 Mar

PMID : 7780638






1 Functional Relationships(s)
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1 DMCM at low concentrations (< 0.5 microM) occupying only the benzodiazepine site decreased GABA-induced Cl currents in the alpha 1 beta 2 gamma 2 and alpha 3 beta 2 gamma 2 subtypes as expected from an inverse agonist, but produced no change in the alpha 6 beta 2 gamma 2 subtype (perhaps a neutral antagonist). Benzodiazepines adrenoceptor alpha 1D Homo sapiens