Pub. Date : 1995 Feb
PMID : 7773300
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the present report, we have characterized culture conditions further by examining individual and interactive effects of dexamethasone (Dex) and PB on CYP2B1, CYP2B2, and CYP3A1 expression. | Phenobarbital | cytochrome P450, family 2, subfamily b, polypeptide 2 | Rattus norvegicus |
| 2 | In contrast, at levels > 10(-7) M, Dex profoundly inhibited PB induction of the CYP2B1 and CYP2B2 genes. | Phenobarbital | cytochrome P450, family 2, subfamily b, polypeptide 2 | Rattus norvegicus |
| 3 | Similarly, concentrations of PB > 0.5 mM resulted in substantially reduced levels of CYP2B1 and CYP2B2 induction than those attainable at lower PB concentrations. | Phenobarbital | cytochrome P450, family 2, subfamily b, polypeptide 2 | Rattus norvegicus |
| 4 | These results suggest that Dex and PB function cooperatively to regulate the CYP2B1 and CYP2B2 genes, and that composite interactions may either negatively or positively regulate expression, in a concentration-dependent manner. | Phenobarbital | cytochrome P450, family 2, subfamily b, polypeptide 2 | Rattus norvegicus |