Title : Lack of correlation between expression and function of P-glycoprotein in acute myeloid leukemia cell lines.

Pub. Date : 1995 May

PMID : 7769842






2 Functional Relationships(s)
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1 When P-gp function was assessed by Rhodamine 123 (Rh123) efflux kinetics, we found that only KG1a and KG1 cells, which have an early (immature) CD34+ CD33- CD38- phenotype, and to a lesser extent TF1, with an intermediate (CD34+ CD33+ CD38+) phenotype, displayed significant P-gp activity which could be inhibited by both verapamil and SDZ PSC 833. Rhodamine 123 ATP binding cassette subfamily B member 1 Homo sapiens
2 When P-gp function was assessed by Rhodamine 123 (Rh123) efflux kinetics, we found that only KG1a and KG1 cells, which have an early (immature) CD34+ CD33- CD38- phenotype, and to a lesser extent TF1, with an intermediate (CD34+ CD33+ CD38+) phenotype, displayed significant P-gp activity which could be inhibited by both verapamil and SDZ PSC 833. Rhodamine 123 ATP binding cassette subfamily B member 1 Homo sapiens