Title : Influence of intracellular renin on heart cell communication.

Pub. Date : 1995 Jun

PMID : 7768559






4 Functional Relationships(s)
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1 The effect of renin on junctional conductance seems to be mainly due to the synthesis of Ang II because enalaprilat (10(-9) mol/L) dialyzed into the cell caused an appreciable reduction in the effect of renin. Enalaprilat renin Rattus norvegicus
2 The effect of renin on junctional conductance seems to be mainly due to the synthesis of Ang II because enalaprilat (10(-9) mol/L) dialyzed into the cell caused an appreciable reduction in the effect of renin. Enalaprilat renin Rattus norvegicus
3 The intracellular administration of renin (0.2 pmol/L) plus angiotensinogen (0.4 pmol/L) produced a faster and stronger fall in junctional conductance (84.3 +/- 1.35%, P < .05), and the effect was greatly reduced by enalaprilat. Enalaprilat renin Rattus norvegicus
4 Moreover, renin dialyzed into just one cell of the pair induced rectification of the junctional membrane, which was prevented by enalaprilat. Enalaprilat renin Rattus norvegicus