Title : [3H]BQ-123, a highly specific and reversible radioligand for the endothelin ETA receptor subtype.

Pub. Date : 1995 Feb 14

PMID : 7768260






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 [3H]BQ-123 binding was sensitive to endothelin-1 and endothelin-2 (Ki values = 0.058 and 0.10 nM, respectively) and the endothelin ETA receptor-selective antagonist BQ-123 (Ki = 3.3 nM), while showing low affinity for endothelin-3 (Ki = 50 nM), the endothelin ETB receptor-selective agonist BQ-3020 (Ki = 970 nM) and other bioactive peptides. Tritium endothelin 1 Homo sapiens