Title : cAMP-associated inhibition of phenobarbital-inducible cytochrome P450 gene expression in primary rat hepatocyte cultures.

Pub. Date : 1995 May 26

PMID : 7759530






2 Functional Relationships(s)
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1 A requirement for protein kinase A (PKA) was demonstrated by the use of (Sp)-cAMPS, a highly specific activator of PKA, whereas the inactive diastereoisomer, (Rp)-cAMPS, was ineffective in modulating PB induction. Phenobarbital protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus
2 A requirement for protein kinase A (PKA) was demonstrated by the use of (Sp)-cAMPS, a highly specific activator of PKA, whereas the inactive diastereoisomer, (Rp)-cAMPS, was ineffective in modulating PB induction. Phenobarbital protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus