Title : Thrombin decreases the urokinase receptor and surface-localized fibrinolysis in cultured endothelial cells.

Pub. Date : 1995 Mar

PMID : 7749851






4 Functional Relationships(s)
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1 The thrombin receptor activation peptide but not control peptide showed a similar but reduced decrease in the specific binding of 125I-labeled tcu-PA to u-PAR. Iodine-125 coagulation factor II, thrombin Homo sapiens
2 Incubation of thrombin-treated cultures (10 to 12 hours) in complete medium restored 125I-labeled tcu-PA ligand binding to normal levels. Iodine-125 coagulation factor II, thrombin Homo sapiens
3 Decreased thrombin-induced 125I-labeled tcu-PA binding correlated with the time-dependent decrease in surface-localized plasmin generation, as measured by the direct activation of 125I-labeled Glu-plasminogen and quantification of the 20-kD light chains of 125I-labeled plasmin. Iodine-125 coagulation factor II, thrombin Homo sapiens
4 Decreased thrombin-induced 125I-labeled tcu-PA binding correlated with the time-dependent decrease in surface-localized plasmin generation, as measured by the direct activation of 125I-labeled Glu-plasminogen and quantification of the 20-kD light chains of 125I-labeled plasmin. Iodine-125 coagulation factor II, thrombin Homo sapiens