Pub. Date : 1995 May
PMID : 7745012
18 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Interleukin-1 stimulates prostaglandin E production by human trophoblast cells from first and third trimesters. | Prostaglandins E | interleukin 1 alpha | Homo sapiens |
| 2 | Interleukin-1 (IL-1) is a known mediator of prostaglandin E (PGE) production in various cell types, including endothelial, amniotic, and endometrial cells; however, its role in the regulation of PGE production in the trophoblast cells is yet unknown. | Prostaglandins E | interleukin 1 alpha | Homo sapiens |
| 3 | Interleukin-1 (IL-1) is a known mediator of prostaglandin E (PGE) production in various cell types, including endothelial, amniotic, and endometrial cells; however, its role in the regulation of PGE production in the trophoblast cells is yet unknown. | Prostaglandins E | interleukin 1 alpha | Homo sapiens |
| 4 | Interleukin-1 (IL-1) is a known mediator of prostaglandin E (PGE) production in various cell types, including endothelial, amniotic, and endometrial cells; however, its role in the regulation of PGE production in the trophoblast cells is yet unknown. | Prostaglandins E | interleukin 1 alpha | Homo sapiens |
| 5 | Interleukin-1 (IL-1) is a known mediator of prostaglandin E (PGE) production in various cell types, including endothelial, amniotic, and endometrial cells; however, its role in the regulation of PGE production in the trophoblast cells is yet unknown. | Prostaglandins E | interleukin 1 alpha | Homo sapiens |
| 6 | Interleukin-1 (IL-1) is a known mediator of prostaglandin E (PGE) production in various cell types, including endothelial, amniotic, and endometrial cells; however, its role in the regulation of PGE production in the trophoblast cells is yet unknown. | Prostaglandins E | interleukin 1 alpha | Homo sapiens |
| 7 | Interleukin-1 (IL-1) is a known mediator of prostaglandin E (PGE) production in various cell types, including endothelial, amniotic, and endometrial cells; however, its role in the regulation of PGE production in the trophoblast cells is yet unknown. | Prostaglandins E | interleukin 1 alpha | Homo sapiens |
| 8 | IL-1 induced a 5-fold increase in PGE production, a response that was cell density, time, and dose dependent. | Prostaglandins E | interleukin 1 alpha | Homo sapiens |
| 9 | IL-1-induced PGE biosynthesis was prevented in the presence of either IL-1 receptor antagonist or the soluble IL-1 receptor, suggesting a receptor-mediated response. | Prostaglandins E | interleukin 1 alpha | Homo sapiens |
| 10 | IL-1-induced PGE biosynthesis was prevented in the presence of either IL-1 receptor antagonist or the soluble IL-1 receptor, suggesting a receptor-mediated response. | Prostaglandins E | interleukin 1 alpha | Homo sapiens |
| 11 | Significantly, de novo production of PGE by trophoblast cells in the absence of IL-1 was also markedly (50%) reduced by either the IL-1 receptor antagonist or the soluble IL-1 receptor, further supporting the notion that IL-1 is involved in PGE synthesis even under basal conditions. | Prostaglandins E | interleukin 1 alpha | Homo sapiens |
| 12 | Significantly, de novo production of PGE by trophoblast cells in the absence of IL-1 was also markedly (50%) reduced by either the IL-1 receptor antagonist or the soluble IL-1 receptor, further supporting the notion that IL-1 is involved in PGE synthesis even under basal conditions. | Prostaglandins E | interleukin 1 alpha | Homo sapiens |
| 13 | Significantly, de novo production of PGE by trophoblast cells in the absence of IL-1 was also markedly (50%) reduced by either the IL-1 receptor antagonist or the soluble IL-1 receptor, further supporting the notion that IL-1 is involved in PGE synthesis even under basal conditions. | Prostaglandins E | interleukin 1 alpha | Homo sapiens |
| 14 | Significantly, de novo production of PGE by trophoblast cells in the absence of IL-1 was also markedly (50%) reduced by either the IL-1 receptor antagonist or the soluble IL-1 receptor, further supporting the notion that IL-1 is involved in PGE synthesis even under basal conditions. | Prostaglandins E | interleukin 1 alpha | Homo sapiens |
| 15 | Transforming growth factor-beta 1, a putative modulator of the effects of IL-1, significantly attenuated IL-1-stimulated PGE production, supporting the possibility that transforming growth factor-beta 1 may serve as a regulator of the effects of IL-1 in trophoblast cells. | Prostaglandins E | interleukin 1 alpha | Homo sapiens |
| 16 | Transforming growth factor-beta 1, a putative modulator of the effects of IL-1, significantly attenuated IL-1-stimulated PGE production, supporting the possibility that transforming growth factor-beta 1 may serve as a regulator of the effects of IL-1 in trophoblast cells. | Prostaglandins E | interleukin 1 alpha | Homo sapiens |
| 17 | Transforming growth factor-beta 1, a putative modulator of the effects of IL-1, significantly attenuated IL-1-stimulated PGE production, supporting the possibility that transforming growth factor-beta 1 may serve as a regulator of the effects of IL-1 in trophoblast cells. | Prostaglandins E | interleukin 1 alpha | Homo sapiens |
| 18 | These observations suggest a pivotal role of IL-1 in the regulation of PGE economy by trophoblast cells. | Prostaglandins E | interleukin 1 alpha | Homo sapiens |