Title : Development of a novel recombinant serpin with potential antithrombotic properties.

Pub. Date : 1995 May 19

PMID : 7744836






2 Functional Relationships(s)
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1 For example, replacement of the P2 proline of Arg-alpha 1-antitrypsin by glycine decreased the association rate constant (kass) with thrombin by 37-fold while the kass value with APC was reduced by only 16-fold. Proline coagulation factor II, thrombin Homo sapiens
2 Substitution of proline for the P2 glycine of this chimeric serpin increased the kass values with thrombin and APC by 7- and 90-fold, respectively. Proline coagulation factor II, thrombin Homo sapiens