Title : Generation of a drug resistance profile by quantitation of mdr-1/P-glycoprotein in the cell lines of the National Cancer Institute Anticancer Drug Screen.

Pub. Date : 1995 May

PMID : 7738186






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Evidence that these compounds are P-glycoprotein substrates includes: (a) enhancement of cytotoxicity by verapamil; (b) demonstration of cross-resistance in a multidrug-resistant cell line, (c) ability to antagonize P-glycoprotein, increasing vinblastine accumulation by decreasing efflux; and (d) inhibition of photoaffinity labeling by azidopine. Vinblastine ATP binding cassette subfamily B member 1 Homo sapiens