Title : 5-Lipoxygenase is located in the euchromatin of the nucleus in resting human alveolar macrophages and translocates to the nuclear envelope upon cell activation.

Pub. Date : 1995 May

PMID : 7738170






2 Functional Relationships(s)
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Compound Name
Protein Name
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1 5-Lipoxygenase (5-LO) and 5-lipoxygenase-activating protein (FLAP) are two key proteins involved in the synthesis of leukotrienes (LT) from arachidonic acid. Leukotrienes arachidonate 5-lipoxygenase activating protein Homo sapiens
2 These results indicate that the nuclear envelope is the site at which 5-LO interacts with FLAP and arachidonic acid to catalyze LT synthesis in activated AM as well as PBL, and that in resting AM the euchromatin region of the nucleus is the predominant source of the translocated enzyme. Leukotrienes arachidonate 5-lipoxygenase activating protein Homo sapiens