Title : Potentiation of anticancer-drug cytotoxicity by multidrug-resistance chemosensitizers involves alterations in membrane fluidity leading to increased membrane permeability.

Pub. Date : 1995 Mar 15

PMID : 7737146






1 Functional Relationships(s)
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1 We show here that the chemosensitizers, reserpine and verapamil, display a dramatic potentiation of taxol, anthracycline and Vinca alkaloids cytotoxicity in P-glycoprotein-(P-gp)-deficient hamster and human nasopharyngeal carcinoma cells. Reserpine phosphoglycolate phosphatase Homo sapiens