Title : Presynaptic actions of morphine: blockade of cholecystokinin-induced noradrenaline release in the rat supraoptic nucleus.

Pub. Date : 1995 Jan 1

PMID : 7730990






4 Functional Relationships(s)
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1 This study aimed to establish the site at which morphine acts to inhibit oxytocin release in response to peripheral administration of cholecystokinin (CCK). Morphine cholecystokinin Rattus norvegicus
2 Inclusion of morphine in the dialysate also blocked the increase in noradrenaline and serotonin in response to CCK in a naloxone-reversible manner. Morphine cholecystokinin Rattus norvegicus
3 These observations indicate that morphine acts near or within the supraoptic nucleus to block CCK-evoked noradrenaline release presynaptically. Morphine cholecystokinin Rattus norvegicus
4 This presynaptic action of morphine may be a cause of the blockade of oxytocin release after CCK. Morphine cholecystokinin Rattus norvegicus