Title : Biphasic effect of interleukin-1 beta on arginine vasopressin-induced cellular cyclic adenosine monophosphate production in cultured rat renal papillary collecting tubule cells.

Pub. Date : 1995 Apr

PMID : 7711886






3 Functional Relationships(s)
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1 A 10-min exposure of cells to IL-1 beta at a concentration of 1 x 10(-12) mol/l or higher significantly reduced the AVP-induced increases in cellular cAMP production but did not affect the 2 x 10(-8) mol/l forskolin-induced increases in cellular cAMP production. Colforsin interleukin 1 beta Rattus norvegicus
2 The IL-1 beta inhibition disappeared totally when cells were pretreated with 100 micrograms/l pertussis toxin for 2 h. In contrast, more than a 30-min exposure of cells to IL-1 beta increased basal cAMP levels and enhanced both the AVP-and forskolin-induced increases in cellular cAMP production. Colforsin interleukin 1 beta Rattus norvegicus
3 The IL-1 beta inhibition disappeared totally when cells were pretreated with 100 micrograms/l pertussis toxin for 2 h. In contrast, more than a 30-min exposure of cells to IL-1 beta increased basal cAMP levels and enhanced both the AVP-and forskolin-induced increases in cellular cAMP production. Colforsin interleukin 1 beta Rattus norvegicus