Title : Evidence for electrogenic sodium-bicarbonate cotransport in cultured rat cerebellar astrocytes.

Pub. Date : 1994 Nov

PMID : 7708483






4 Functional Relationships(s)
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1 Removal of external Na+ also caused a fall of pHi, and addition of CO2/HCO3- in Na(+)-free saline evoked a further fall of pHi, while the outward current was reduced or even reversed. Bicarbonates glucose-6-phosphate isomerase Rattus norvegicus
2 The stilbene 4,4"-diisothiocyanatostilbene-2,2"-disulphonic acid (DIDS, 0.3 mM) reduced the pHi recovery from the CO2/HCO3(-)-evoked acidification, and blocked the prominent intracellular acidification upon removal of CO2/HCO3-. Bicarbonates glucose-6-phosphate isomerase Rattus norvegicus
3 The stilbene 4,4"-diisothiocyanatostilbene-2,2"-disulphonic acid (DIDS, 0.3 mM) reduced the pHi recovery from the CO2/HCO3(-)-evoked acidification, and blocked the prominent intracellular acidification upon removal of CO2/HCO3-. Bicarbonates glucose-6-phosphate isomerase Rattus norvegicus
4 The results suggest that the CO2/HCO3(-)-dependent current is partly due to a reversible bidirectional, electrogenic Na(+)-HCO3- cotransporter, which helps to regulate pHi in these cells. Bicarbonates glucose-6-phosphate isomerase Rattus norvegicus