Title : Physiologic mechanisms of action of lovastatin in nephrotic syndrome.

Pub. Date : 1995 Jan

PMID : 7706943






3 Functional Relationships(s)
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1 Lovastatin (20 mg/day) significantly decreased cholesterol (27.6 +/- 6%), LDL-cholesterol (27.6 +/- 9%) and plasma apoB (17.9 +/- 2.9%) (P < 0.01 for all). Lovastatin apolipoprotein B Homo sapiens
2 Lovastatin significantly decreased LDL-apoB production rate in all cases (34.1 +/- 14%, P = 0.03). Lovastatin apolipoprotein B Homo sapiens
3 Thus, lovastatin decreased LDL-cholesterol in nephrotic subjects mainly by inhibiting LDL-apoB production from VLDL. Lovastatin apolipoprotein B Homo sapiens