Title : Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2.

Pub. Date : 1995 Apr

PMID : 7706493






1 Functional Relationships(s)
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1 In F-nl, incubation with the agonists PMA, LPS, or IL-1 increased COX activity and protein expression of the inducible form of COX, COX-2, and these responses were inhibited by coincubation with dexamethasone. Dexamethasone mitochondrially encoded cytochrome c oxidase II Homo sapiens