Title : Adenylate cyclase, cyclic AMP and extracellular-signal-regulated kinase-2 in airway smooth muscle: modulation by protein kinase C and growth serum.

Pub. Date : 1995 Mar 15

PMID : 7702566






3 Functional Relationships(s)
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1 We have previously demonstrated that, in order to induce full activation of ERK-2 with bradykinin, it is necessary to obliterate PKC-stimulated cyclic AMP formation. Cyclic AMP mitogen-activated protein kinase 1 Homo sapiens
2 We concluded that the cyclic AMP signal limits the magnitude of ERK-2 activation [Pyne, Moughal, Stevens, Tolan and Pyne (1994) Biochem. Cyclic AMP mitogen-activated protein kinase 1 Homo sapiens
3 The present study indicates that the bradykinin-stimulated ERK-2 pathway is entirely cyclic AMP-sensitive, and suggests that coincident signal detection by adenylate cyclase may be an important physiological route for the modulation of early mitogenic signalling. Cyclic AMP mitogen-activated protein kinase 1 Homo sapiens