Pub. Date : 1993
PMID : 7694703
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pharmacologic control of histamine release from human basophils induced by platelet-activating factor. | Histamine | PCNA clamp associated factor | Homo sapiens |
| 2 | We studied the effect of several compounds that influence different cell activation steps on platelet-activating factor (PAF)-induced basophil histamine secretion. | Histamine | PCNA clamp associated factor | Homo sapiens |
| 3 | We studied the effect of several compounds that influence different cell activation steps on platelet-activating factor (PAF)-induced basophil histamine secretion. | Histamine | PCNA clamp associated factor | Homo sapiens |
| 4 | Rolipram (phosphodiesterase, PDE, isotype IV inhibitor; 0.1 nM-10 microM) potently inhibited histamine secretion activated by PAF, whereas SKF95654 (PDE III inhibitor; 0.01-10 microM) was ineffective. | Histamine | PCNA clamp associated factor | Homo sapiens |
| 5 | The kinase inhibitor, staurosporine (0.1-100 nM), enhanced PAF-induced basophil histamine release, whereas the G-protein inhibitor, pertussis toxin (1 microgram/ml), had an inhibitory effect. | Histamine | PCNA clamp associated factor | Homo sapiens |
| 6 | The specific lipoxygenase inhibitor, AA-861 (0.1-10 microM), inhibited PAF-activated histamine release, while the leukotriene A4 hydrolase inhibitor, bestatin (100 microM), had only a marginal effect. | Histamine | PCNA clamp associated factor | Homo sapiens |
| 7 | Finally, the Ca2+ channel entry blockers, verapamil (3-30 microM) and zinc (1.5-50 microM), inhibited PAF-induced histamine release. | Histamine | PCNA clamp associated factor | Homo sapiens |