Pub. Date : 1993 Nov 5
PMID : 7693684
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CsA and FK506 inhibited depolarization-induced glucagon gene transcription, FK506 being more potent than CsA. | Tacrolimus | ERCC excision repair 8, CSA ubiquitin ligase complex subunit | Homo sapiens |
| 2 | CsA/FK506 responsiveness was mediated by the glucagon CRE and also by well characterized CREs of the choriogonadotropin and somatostatin genes. | Tacrolimus | ERCC excision repair 8, CSA ubiquitin ligase complex subunit | Homo sapiens |
| 3 | Rapamycin antagonized the inhibitory effect of FK506 but not CsA, suggesting that FK506 and CsA may act through complex formation with distinct intracellular immunophilins. | Tacrolimus | ERCC excision repair 8, CSA ubiquitin ligase complex subunit | Homo sapiens |
| 4 | The interference with CRE-mediated gene transcription represents a novel mechanism of CsA/FK506 action, which may underlie pharmacological effects and toxic manifestations of these potent immunosuppressive drugs. | Tacrolimus | ERCC excision repair 8, CSA ubiquitin ligase complex subunit | Homo sapiens |