Pub. Date : 1993 Oct
PMID : 7691887
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In a model of pulmonary inflammation and fibrosis induced by the antineoplastic antibiotic, bleomycin, we previously demonstrated that TGF-beta was markedly elevated within 7 d of bleomycin administration. | Bleomycin | transforming growth factor, beta 1 | Rattus norvegicus |
| 2 | In a model of pulmonary inflammation and fibrosis induced by the antineoplastic antibiotic, bleomycin, we previously demonstrated that TGF-beta was markedly elevated within 7 d of bleomycin administration. | Bleomycin | transforming growth factor, beta 1 | Rattus norvegicus |
| 3 | In this study, we have demonstrated that alveolar macrophages stimulated by bleomycin-induced injury secrete large quantities of biologically active TGF-beta 1 when explanted into tissue culture. | Bleomycin | transforming growth factor, beta 1 | Rattus norvegicus |
| 4 | High doses of the corticosteroid methylprednisolone given intramuscularly before and concomitantly with bleomycin administration prevented the influx of alveolar macrophages into the lungs, diminishing both the number of macrophages present in the alveoli and the total lung content of TGF-beta. | Bleomycin | transforming growth factor, beta 1 | Rattus norvegicus |
| 5 | The findings in this study demonstrate that during bleomycin-induced injury, alveolar macrophages not only secrete large quantities of active TGF-beta 1, but are a predominant source of the enhanced TGF-beta response seen in this model. | Bleomycin | transforming growth factor, beta 1 | Rattus norvegicus |
| 6 | The findings in this study demonstrate that during bleomycin-induced injury, alveolar macrophages not only secrete large quantities of active TGF-beta 1, but are a predominant source of the enhanced TGF-beta response seen in this model. | Bleomycin | transforming growth factor, beta 1 | Rattus norvegicus |